RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-18a-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay etc.
Target
Tgf-brii
Pathway
TGF-B/SMAD2/SMAD3 signaling pathway
PubMed ID
Title
MiR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-B Receptor II
Year
2017
Function
"MiR-18a-5p was reduced in PMCs treated with bleomycin, contributing to EMT of PMCs.MiR-18a-5p binds to the 3' UTR region of transforming growth factor B receptor II (TGF-BRII) mRNA, and this is associated with reduced TGF-BRII expression and suppression of TGF-B-Smad2/3 signaling. Overexpression of miR-18a-5p prevented bleomycin-induced EMT of PMC and inhibited bleomycin-induced sub-pleural fibrosis in mice."